Long‐term effects of coronavirus disease 2019 on diabetes complications and mortality in people with diabetes: Two cohorts in the UK and Hong Kong
Authors' conclusion
COVID-19 infection is associated with long-term increased risks of diabetes complications (especially cardiovascular complications, and mortality) in people with diabetes. Monitoring for signs/symptoms of developing these long-term complications post-COVID-19 infection in the infected patient population of people with diabetes may be beneficial in minimizing their morbidity and mortality.
Study context
- Population
- People with diabetes, UK Biobank and Hong Kong electronic health recordsmatched cohorts
- Participants
- 2,456 / 41,801 / 80,546 / 391,849
- Exposure
- COVID-19 infection vs no COVID-19 in people with diabetes
- Exposed (UKB)n = 2,456
- Unexposed (UKB)n = 41,801reference
- Exposed (HK)n = 80,546
- Unexposed (HK)n = 391,849reference
- Outcome
- Multi-organ disease complications and all-cause mortality after 21 days of diagnosis (Cox regression)
- Follow-up
- Up to 18 months (UKB); up to 28 months (HK)
Methodological detailstwo cohorts (UK Biobank and Hong Kong), matched on age and sex, Inverse Probability Treatment Weighting
- Two cohorts (UK Biobank and Hong Kong)
- Matched on age and sex
- Inverse Probability Treatment Weighting
Main finding
As reported in the abstract
- CHD, HR (UKB)
- 1.6 (95% CI 1.0, 2.4)
- CHD, HR (HK)
- 1.2 (95% CI 1.0, 1.5)
- Stroke, HR (UKB)
- 2.0 (95% CI 1.1, 3.6)
- Stroke, HR (HK)
- 1.5 (95% CI 1.3, 1.8)
- End stage renal disease, HR (UKB)
- 2.1 (95% CI 1.1, 4.0)
- End stage renal disease, HR (HK)
- 1.2 (95% CI 1.1, 1.4)
- All-cause mortality, HR (UKB)
- 4.6 (95% CI 3.8, 5.5)
- All-cause mortality, HR (HK)
- 2.6 (95% CI 2.5, 2.8)
Observational data: associations, not effects.
Original publication
Long‐term effects of coronavirus disease 2019 on diabetes complications and mortality in people with diabetes: Two cohorts in the UK and Hong Kong. Diabetes Obes Metab. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →