Long-term effect of intensive lifestyle intervention on cardiometabolic risk factors and microvascular complications in patients with diabetes in real-world clinical practice: a 10-year longitudinal study
Authors' conclusion
Weight reduction in patients with diabetes can be maintained for up to 10 years in real-world clinical practice. Sustained weight loss is associated with significantly lower A1c at 10 years and improvement in lipid profile. Maintenance of ≥7% weight loss at 1 year is associated with decreased incidence of diabetic nephropathy at 10 years.
Study context
- Population
- Patients with diabetes and obesity enrolled in a 12-week translational model of intensive lifestyle intervention (ILI)
- Participants
- 129 patients
- Exposure
- Maintained ≥7% vs <7% weight loss at 1 year after 12-week ILI
- Group An = 61reference
- Group Bn = 67
- Outcome
- Weight loss maintained
- Follow-up
- Up to 10 years
Methodological details10-year follow-up, real-world clinical practice
- 10-year follow-up
- Real-world clinical practice
Main finding
As reported in the abstract
| Group | Value | % weight change |
|---|---|---|
| Group A | 4.3 ± 9.5 kg | −4.3% |
| Group B | 10.8 ± 9.3 kg | −9.3% |
Value
Group A4.3 ± 9.5 kg
Group B10.8 ± 9.3 kg
% weight change
Group A−4.3%
Group B−9.3%
- Group B vs Group A: P < 0.001 between groups
- Total cohort weight loss at 12 weeks
- 10.8±4.6 kg (−9.7%)
- Total cohort weight loss maintained at 10 years
- 7.7±10 kg (−6.9%)
Observational data: associations, not effects.
Further findings
A1c · up to 10 years
P < 0.05 between groups
Baseline Group A 7.5±1.3% · Group B 7.4±1.2%
12 weeks Group A 6.7±0.9% · Group B 6.4±0.9%
1 year Group A 7.7±1.4% · Group B 6.8±1.2%
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Nephropathy · up to 10 years68% lower risk | 0.32 (0.11–0.9) | P = 0.007 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Long-term effect of intensive lifestyle intervention on cardiometabolic risk factors and microvascular complications in patients with diabetes in real-world clinical practice: a 10-year longitudinal study. BMJ Open Diabetes Res Care. Published 22 May 2023. doi:10.
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