The association of type 2 diabetes‐related characteristics with fracture risk at different sites
Authors' conclusion
In conclusion, our study shows that a diabetes duration of 10 years or more, strict glycaemic control resulting in HbA1c levels below 6%, and/or the presence of at least one microvascular complication increased the risk of any fracture, hip fractures, MOFs, and humerus fractures, but not ankle, scapula or skull fractures.
Study context
- Population
- Patients aged over 30 years with T2D, Clinical Practice Research Datalink (CPRD) GOLD
- Exposure
- Diabetes duration, HbA1c level and microvascular complications vs reference categories
- Outcome
- Fracture risk at different sites (any fracture, MOFs, hip fracture)
Methodological detailsCox proportional hazards models, adjusted for demographics, comorbidities and comedication
- Cox proportional hazards models
- Adjusted for demographics, comorbidities and comedication
Main finding
As reported in the abstract
Fracture risk by diabetes-related characteristics
- Diabetes duration >10 years vs <2 years: increased risk of any fracture and major osteoporotic fractures (MOFs)
- Diabetes duration >8 years vs <2 years: increased hip fracture risk
- HbA1c <6% vs 6% to <7%: increased fracture risk
- One or two microvascular complications vs none: increased risk of any fracture and MOFs
- Two microvascular complications vs none: increased hip fracture risk
Observational data: associations, not effects.
Original publication
The association of type 2 diabetes‐related characteristics with fracture risk at different sites. Diabetes Obes Metab. Published 2 September 2024. doi:10.
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