Liver fibrosis scores predict cardiovascular outcomes in myocardial infarction and non-obstructive coronary arteries patients with and without diabetes or prediabetes
Authors' conclusion
Elevated LFS predicts a higher risk of MACE in MINOCA, especially in patients with DM/pre-DM, and may aid in risk stratification.
Study context
- Population
- Consecutive myocardial infarction and non-obstructive coronary arteries (MINOCA) patients (mean age 63.7 years; 211 men), 271 with DM/pre-DM271 DM/pre-DM
- Participants
- 406 patients
- Exposure
- High vs low liver fibrosis scores
- Outcome
- MACE
- Follow-up
- 32 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- FIB-4 ≥ 2.67 or NFS ≥ 0.676 independently associated with increased major adverse cardiovascular events (MACE) risk in DM/pre-DM, but not in non-DM/pre-DM (fully adjusted Cox models)
- High liver fibrosis scores (LFS) vs Low LFS: log-rank p < 0.05
Observational data: associations, not effects.
Further findings
Prevalence of high LFS
- High FIB-4
- 38.9%
- High NFS
- 28.3%
Dose-response (restricted cubic spline (RCS))
- Linear association between FIB-4 and MACE; nonlinear for NFS
Original publication
Liver fibrosis scores predict cardiovascular outcomes in myocardial infarction and non-obstructive coronary arteries patients with and without diabetes or prediabetes. Diabetes Res Clin Pract. Published 21 February 2026. doi:10.
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