Lipopolysaccharide-binding protein and bone health: data from a population-based sample of men
Authors' conclusion
Our data do not support a clear association between serum LBP and measures of bone health in this sample of men.
Study context
- Population
- Men aged 20–96 years enrolled in the Geelong Osteoporosis Study
- Participants
- 1,149 men
- Outcome
- Association of serum LBP (ln-LBP) with BMD, quantitative heel US (SI, BUA, SOS) and bone turnover (CTX, P1NP)
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Association of ln-LBP with bone measures
Serum lipopolysaccharide-binding protein (LBP) range
1.07-208.53 ng/mL
Serum LBP median
16.53 ng/mL
Mid-forearm bone mineral density (BMD), after further adjustment for weight (β ± SE)
β - 0.014 ± 0.004
p = 0.001
Weight an effect modifier for ln-LBP and broadband ultrasound attenuation (BUA); BUA in those weighing >82.7 kg, adjusted (β ± SE)
β 3.366 ± 0.929
p < 0.001
Observational data: associations, not effects.
Further findings
Characteristics by LBP level
- Those with higher LBP were older, less mobile and had lower mid-forearm BMD; otherwise groups similar
Original publication
Lipopolysaccharide-binding protein and bone health: data from a population-based sample of men. Osteoporos Int. Published 21 November 2022. doi:10.
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