Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes
Authors' conclusion
Among adults with prediabetes at baseline, lifestyle intervention, but not metformin, was associated with a lower burden of multimorbidity.
Study context
- Population
- Adults with prediabetes at high risk of diabetes enrolled in Diabetes Prevention Program (DPP)/DPP Outcomes Study (DPPOS), 27 US sites, with CMS morbidity data through 2021; median age 74 years, 68% femalewith CMS data
- Participants
- 1,173 adults
- Comparison
- Intensive lifestyle intervention or metformin vs placebo
- Lifestylen = 385
- Metforminn = 385
- Placebon = 403reference
- Primary endpoint
- Multimorbidity (≥2 of 15 prevalent conditions defined in CMS' Chronic Condition Data Warehouse)
- Follow-up
- Through 2021
Methodological detailsDPP/DPPOS, multicentre, 27 sites, long-term follow-up, Cox proportional hazard models, adjusted for relevant covariates
- DPP/DPPOS
- Multicentre
- 27 sites
- Long-term follow-up
- Cox proportional hazard models
- Adjusted for relevant covariates
Primary result
As reported in the abstract
Multimorbidity · end of follow-up
Each group vs placeboHazard ratio (95% CI)
Lifestyleadjusted for relevant covariates
0.79(0.68–0.93)
Metformin
0.91(0.78–1.07)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Multimorbidity restricted to dyads of the costliest conditionsLifestylevs Placebo | 0.57 (0.38–0.85) | |
| 0.20.5125Hazard ratio (log scale) |
Multimorbidity excluding diabetes
- These relationships persisted when diabetes was excluded from the multimorbidity definition
Original publication
Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes. JAMA. Published 18 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →