Levothyroxine for a high‐normal TSH in unexplained infertility
Authors' conclusion
Women with unexplained infertility and high-normal TSH levels treated with levothyroxine had a higher rate of conception but lower live birth rate compared to untreated women, with the limitation of a small sample size. These findings assert the need for prospective, randomized studies to determine whether treatment with levothyroxine in women with unexplained infertility and high-normal TSH is beneficial.
Study context
- Population
- Women evaluated for unexplained infertility with high-normal TSH (2.5–5 mIU/L, within assay normal range), large academic medical centre, 1 January 2000–30 June 2017
- Participants
- 96 women
- Exposure
- Levothyroxine vs no levothyroxine
- Levothyroxinen = 31
- Untreatedn = 65reference
- Outcome
- Conception and live birth rates
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
P = 0.086 unadjusted; p < .05 adjusted for age; p = .370 adjusted for TSH; p = .287 adjusted for age and TSH
Observational data: associations, not effects.
Further findings
Live birth rate · lower with Levothyroxine
P = 0.05 unadjusted; p = .094 adjusted for age; p = .035 adjusted for TSH; p = .057 adjusted for age and TSH
Original publication
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