Measuring Hypothyroidism Disease Control Using a TSH-based “Time-in-range”
Authors' conclusion
We used TIR estimation to identify differences in disease control between sociodemographic groups and the impact of LT4 dose. In future studies, we aim to better characterize the association between TIR and clinically meaningful outcomes.
Study context
- Population
- Adults ≥18 years, levothyroxine (LT4)-treated, with ≥3 unique TSH levels over ≥2 years, single academic institution
- Participants
- 2,752 adults
- Outcome
- TSH-based TIR estimation method and impact of sociodemographic characteristics on TIR
Methodological detailssingle-centre, longitudinal clinical data (2016-2022)
- Single-centre
- Longitudinal clinical data (2016-2022)
Main finding
As reported in the abstract
TIR · study enrollment period (median, 3.8 years)
- Median time-in-range (TIR)
- 86%
- LT4 dose vs TIR correlation, males (P < .001)
- R = −0.23
- LT4 dose vs TIR correlation, females (P < .001)
- R = −0.30
- Male sex associated with TIR <75% (P < .001)
- OR, 1.30
- Black race associated with TIR <75% (P < .001)
- OR, 1.37
Observational data: associations, not effects.
Secondary outcomes
Time-above-range (TAR) and cardiovascular events
- OR per +10% TAR (P = .078; approached significance)
- 1.03
Original publication
Measuring Hypothyroidism Disease Control Using a TSH-based “Time-in-range”. J Clin Endocrinol Metab. Published 12 July 2025. doi:10.
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