Laron syndrome (growth hormone insensitivity). Geographical distribution and relationship to genetic defects in the growth hormone receptor gene
Authors' conclusion
Review of the scientific literature between 1966-2025 revealed 840 patients with Laron Syndrome. Shared ancestors, human migration and the practice of consanguinity explain the geographic distribution of these patients.
Study context
- Population
- Reported patients with Laron syndrome (GH insensitivity due to GH receptor gene defects) worldwide801 publications
- Participants
- 840 patients
- Outcome
- Reported number of patients with LS and their geographical distribution in relation to pathogenic GH-R variants
Methodological detailspublications 1966-2025, PubMed, SCOPUS, EMBASE, ScienceDirect, Web of Science, Google and Cochrane Reviews, patients cited repeatedly included only once
- Publications 1966-2025
- PubMed, SCOPUS, EMBASE, ScienceDirect, Web of Science, Google and Cochrane Reviews
- Patients cited repeatedly included only once
Main finding
As reported in the abstract
Patients with Laron Syndrome (LS) identified
840
Males
412
Females
361
Sex not stated
67
Further findings
GH receptor (GH-R) genetic analysis
- Patients with genetic analysis (out of 411)
- 402
- Different genetic defects
- 109
- Most pathogenic variants in the extracellular domain; fewer in transmembrane or intracellular domains and introns
Original publication
Laron syndrome (growth hormone insensitivity). Geographical distribution and relationship to genetic defects in the growth hormone receptor gene. J Clin Endocrinol Metab. Published 15 July 2026. doi:10.
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