Kidney outcomes of SGLT2 inhibitors among older patients with diabetic kidney disease in real-world clinical practice: the Japan Chronic Kidney Disease Database Ex
Main finding · Mean annual rate of eGFR changeResult — go to the resultDifference in the rate of eGFR decline 0.99 mL/min/1.73 m²/year 95% CI 0.5–1.38Authors' conclusion
The benefits of SGLT2 inhibitors on renal outcomes are also applicable to older patients with DKD aged≥75 years.
Study context
- Population
- Patients with diabetic kidney disease (DKD) aged ≥75 years, with or without proteinuria, Japan Chronic Kidney Disease Database; mean age 77.7 years, mean estimated glomerular filtration rate (eGFR) 59.3 mL/min/1.73m2, proteinuria 230 (33.0%)matched cohort
- Participants
- 348 vs 348
- Exposure
- SGLT2i initiation vs other glucose-lowering drugs
- SGLT2 inhibitorsn = 348
- Other glucose-lowering drugsn = 348reference
- Outcome
- Rate of eGFR decline
- Follow-up
- Throughout
Methodological detailspropensity-score matched, 1:1 matching, real-world
- Propensity-score matched
- 1:1 matching
- Real-world
Main finding
Mean annual rate of eGFR change
Difference in the rate of eGFR decline
0.99 mL/min/1.73 m²/year
95% CI 0.5–1.38
P < 0.001
Change by group
SGLT2i
−0.80
mean · 95% CI −1.05–-0.54 · mL/min/1.73 m²/year
Other glucose-lowering drugs
−1.78
mean · 95% CI −2.08–-1.49 · mL/min/1.73 m²/year
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Other glucose-lowering drugs | HR (95% CI) | |
|---|---|---|---|
| Composite of 40% eGFR reduction or progression to end-stage kidney diseaseSGLT2ivs Other glucose-lowering drugs | 57 events | 0.64 (0.42–0.97) | |
| 0.512Hazard ratio (log scale) |
- Composite of 40% eGFR reduction or progression to end-stage kidney disease: SGLT2i 38 events
Interaction with proteinuria
- No evidence of an interaction between SGLT2i initiation and proteinuria
Original publication
Kidney outcomes of SGLT2 inhibitors among older patients with diabetic kidney disease in real-world clinical practice: the Japan Chronic Kidney Disease Database Ex. BMJ Open Diabetes Res Care. Published 30 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →