Joint association of the triglyceride–glucose index and stress hyperglycemia ratio with incidence and mortality risks of new-onset atrial fibrillation during sepsis: a retrospective cohort study
Authors' conclusion
The TyG index and SHR were associated with the incidence of in-hospital NOAF during sepsis, although their predictive powers were limited. In septic patients with in-hospital NOAF, high levels of the TyG index and SHR were significantly associated with increased 360-day mortality risks, with their combination demonstrating superior predictive power. Joint assessments of the TyG index and SHR could help identify individuals at high risks of mortality post-discharge, enabling clinicians to prioritize follow-up care and improve patient management.
Study context
- Population
- Patients with sepsis, MIMIC-IV database764 developed new-onset atrial fibrillation (NOAF)
- Participants
- 4,276 patients
- Exposure
- Highest vs lowest triglyceride-glucose (TyG) index, stress hyperglycemia ratio (SHR) and TyG index-SHR combination groups
- Outcome
- Incidence and 360-day mortality of in-hospital NOAF
Methodological detailsMIMIC-IV database, machine learning (random forest)
- MIMIC-IV database
- Machine learning (random forest)
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prediction of 360-day mortality in septic patients with NOAF (ROC, random forest)
- TyG index-SHR combination had more robust predictive power than TyG index and SHR alone
- P < 0.05
- Random forest: predictive capability significantly enhanced with integration of TyG index and SHR
Original publication
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