Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study
Main finding · Overall CVDResult — go to the resultHazard ratio 2.632 95% CI 1.695–4.085Authors' conclusion
The study demonstrates that both elevated UACR (within normal range) and higher TyG index are jointly associated with increased CVD risk, with evidence suggesting potential bidirectional mediation. Their combined assessment provides significant incremental predictive value, supporting its integration into high-risk population screening for precise CVD prevention and management.
Study context
- Population
- Adults with normal urinary albumin-to-creatinine ratio (UACR) (<30 mg/g), 2016 Shandong-MOH Salt and Hypertension (SMASH) project; mean age 41.75 ± 13.06 years420 incident cardiovascular disease (CVD) cases
- Participants
- 14,481 adults
- Exposure
- Joint triglyceride-glucose (TyG) index and UACR categories
- Outcome
- Overall CVD, CHD and stroke
- Follow-up
- Median 7.2 years
Main finding
Overall CVD
Hazard ratio
2.632
95% CI 1.695–4.085
P < 0.001
High TyG & High UACRvs Low TyG & Low UACR
HR 2.632 (95% CI 1.695–4.085); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CHD | 2.680 (1.144–6.282) | P = 0.023 | |
| Stroke | 2.628 (1.573–4.392) | P < 0.001 | |
| 0.10.31310Hazard ratio (log scale) |
Dose-response and prediction
- TyG index nonlinear with overall CVD and stroke, linear with coronary heart disease (CHD); UACR linear positive with all outcomes
- Combined TyG index and UACR model significantly enhanced CVD prediction
Mediation analysis
- Elevated UACR mediated share of TyG–CVD association
- 4.9%
- Elevated TyG index mediated share of UACR–CVD association
- 11.2%
- Exploratory
Original publication
Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study. Cardiovasc Diabetol. Published 28 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →