Joint association of triglyceride glucose index (triglyceride glucose (TyG)) and body roundness index (BRI) with stroke incidence: a national cohort study
Authors' conclusion
We discovered that both the TyG index and BRI are strongly associated with stroke incidence. The joint assessment of TyG and BRI enhances the predictive capability for stroke, underscoring the critical role of IR and visceral adiposity in the identification and screening of stroke risk.
Study context
- Population
- Adults aged ≥45 years free of stroke at baseline, China Health and Retirement Longitudinal Study (CHARLS); mean (SD) age 58.06 (8.57) years, 44.6% male
- Participants
- 6,621 adults
- Exposure
- TyG index and/or BRI categories vs low TyG and low BRI
- Outcome
- Incident stroke
- Follow-up
- Up to 9 years
Methodological detailsnational cohort, Cox proportional hazards regression, additive and multiplicative interaction analysis
- National cohort
- Cox proportional hazards regression
- Additive and multiplicative interaction analysis
Main finding
As reported in the abstract
Incident stroke (743 events) · up to 9 years
Each group vs low TyG + low BRIAdjusted hazard ratio (95% CI)
High TyG alone
1.36(1.05–1.75)
High BRI alone
1.61(1.27–2.05)
High TyG + high BRI
1.78(1.40–2.26)
Observational data: associations, not effects.
Further findings
Interaction between BRI and TyG
- Neither additive nor multiplicative interactions were statistically significant
Stroke prediction
- TyG + BRI combined enhanced stroke prediction vs either biomarker alone
Original publication
Joint association of triglyceride glucose index (TyG) and body roundness index (BRI) with stroke incidence: a national cohort study. Cardiovasc Diabetol. Published 16 April 2025. doi:10.
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