Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study
Authors' conclusion
The combined prediction of TyG and ABSI had higher clinical value and enabled earlier detection of the stroke in the general population, which could be monitored and intervened to reduce the overall burden of stroke.
Study context
- Population
- Adults aged ≥45 years without stroke, China Health and Retirement Longitudinal Study (CHARLS); followed up to 9 years
- Participants
- 8,257 adults
- Exposure
- TyG and ABSI, alone and combined, as predictors of stroke incidence
- Outcome
- Stroke incidence
- Follow-up
- Up to 9 years
Methodological detailsnationwide, China Health and Retirement Longitudinal Study (CHARLS)
- Nationwide
- China Health and Retirement Longitudinal Study (CHARLS)
Main finding
As reported in the abstract
| Group | Adjusted HR | AUC |
|---|---|---|
| TyG | 1.25 (95%CI: 1.06-1.47) | 0.566 (95%CI: 0.544-0.587) |
| ABSI | 1.33 (95%CI: 1.06-1.68) | 0.533 (95%CI: 0.524-0.597) |
| TyG + ABSI | 0.579 (95%CI: 0.553-0.597) |
Adjusted HR
TyG1.25 (95%CI: 1.06-1.47)
ABSI1.33 (95%CI: 1.06-1.68)
TyG + ABSI— not stated in the abstract
AUC
TyG0.566 (95%CI: 0.544-0.587)
ABSI0.533 (95%CI: 0.524-0.597)
TyG + ABSI0.579 (95%CI: 0.553-0.597)
- Stroke incidence, all participants
- 672 (8.14%)
- Highest cumulative stroke incidence with high TyG and ABSI (TyG ≥ 8.5742, ABSI ≥ 0.0852); Kaplan-Meier
- P < 0.0001
- HR of stroke incidence, high TyG and ABSI (highest)
- 1.64 (95%CI: 1.2-2.24)
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline)
- Restricted cubic spline regression showed associations between TyG or ABSI and stroke
Original publication
Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 6 January 2025. doi:10.
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