The joint association of the combined triglyceride-glucose index and atherogenic index of plasma with hypertension on stroke risk across different glycemic status: a prospective cohort study
Authors' conclusion
TyG-AIP is associated with increased stroke risk, particularly in dysglycemic individuals, and exhibits joint effects with hypertension. The integration of TyG-AIP assessment with hypertension status enhances risk stratification, supporting comprehensive management of both metabolic and hemodynamic factors in stroke prevention.
Study context
- Population
- Participants with dysglycemia or normoglycemia, followed for stroke460 incident strokes
- Participants
- 5,786 participants
- Exposure
- Higher vs lower TyG-AIP, alone and jointly with hypertension
- PDMn = 3,490
- NDMn = 2,296
- Outcome
- Incident stroke
- Follow-up
- 8 years
Methodological detailsK-means clustering of TyG-AIP trajectories, multivariable Cox proportional hazards models
- K-means clustering of TyG-AIP trajectories
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
HR per SD increase in TyG-AIP, all participants
HR = 1.35, 95% CI 1.21-1.51
P < 0.001
HR in those with dysglycemia
HR = 1.54, 95% CI 1.21-1.95
P < 0.001
Observational data: associations, not effects.
Further findings
Nonlinear association of TyG-AIP with stroke
- P for nonlinearity
- 0.002
Joint high TyG-AIP and hypertension
- Synergistic interaction; both high TyG-AIP and hypertension had greatest risk, HR
- 2.89 (2.22-3.76) (95% CI)
"High-and-declining" TyG-AIP trajectory, PDM
- Highest stroke risk, HR (95% CI); P
- 2.26 (1.62-3.15); P < 0.001
Discrimination (ROC)
- AUC, TyG-AIP + hypertension
- 0.643
- AUC, hypertension alone
- 0.571
Original publication
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