Isocaloric replacement of ultraprocessed foods was associated with greater weight loss in the Preventing Overweight Using Novel Dietary Strategies (POUNDS) Lost trial
Authors' conclusion
Isocaloric substitution of UPFs with NOVA 1 + 2 was associated with marginally greater weight loss under energy restriction. These modest findings support more research exploring the mechanisms linking UPFs with body weight regulation beyond energy intake.
Study context
- Population
- POUNDS Lost trial participants with 24-h dietary recalls; mean age 52.3 years, 85% White, 55% female, 58.2% nonsmoking, mean BMI 32.7 kg/m²trial subset
- Participants
- 356 participants
- Comparison
- Isocaloric replacement of ultraprocessed foods (UPFs) (NOVA 4) with minimally processed foods and culinary ingredients (NOVA 1 + 2)
- Primary endpoint
- Weight change associated with replacing %kcal from UPFs with NOVA 1 + 2
- Follow-up
- 6 months
Methodological detailssecondary prospective analysis, multivariable-adjusted substitution models
- Secondary prospective analysis
- Multivariable-adjusted substitution models
Primary result
As reported in the abstract
Weight reduction per 10%kcal of UPFs replaced with NOVA 1 + 2
ß
0.51
95% CI −0.93 to −0.09
P = 0.02
Further findings
kg
| Outcome | T3 | T1 | ß (95% CI) | P value |
|---|---|---|---|---|
| Weight loss by NOVA 1 + 2 tertile · 6 monthsGreater weight loss with T3 | −8.33 | −5.32 | P < 0.001 | |
| Body fat percentage reduction per 10%kcal of UPFs replaced with NOVA 1 + 2 · 6 monthsBetween NOVA 1 + 2 and UPFs · associated with greater body fat percentage reduction | 2.7 (−5.10 to −0.43) | P = 0.02 | ||
| Trunk fat reduction per 10%kcal of UPFs replaced with NOVA 1 + 2 · 6 monthsBetween NOVA 1 + 2 and UPFs · associated with greater trunk fat reduction | 3.9 (−7.01 to −0.70) | P = 0.02 |
Waist circumference reduction · 6 months
- Replacing UPFs with NOVA 1 + 2 not associated with greater waist circumference reduction
Original publication
Isocaloric replacement of ultraprocessed foods was associated with greater weight loss in the POUNDS Lost trial. Obesity (Silver Spring). Published 27 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →