Islet autoimmunity in young First Nations women with prediabetes and type 2 diabetes
Authors' conclusion
The proportion of individual autoantibody positivity among younger First Nations women with prediabetes or type 2 diabetes was 9%. Islet autoantibody positivity was not associated with a distinct clinical phenotype in this group. Longitudinal follow-up will allow assessment of glycaemic trajectories and clinical outcomes in younger First Nations women.
Study context
- Population
- Young First Nations women with prediabetes or T2D, screened for GADA, IA-2 and ZnT8 autoantibodies (3Screen ELISA, then individual autoantibody ELISA)
- Participants
- 180 women
- Exposure
- Prediabetes vs T2D
- Prediabetesn = 51
- T2Dn = 129
- Outcome
- Prevalence of islet autoimmunity
Main finding
As reported in the abstract
Positive for ≥1 individual autoantibody on ELISA
- Positive on 3Screen and for ≥1 individual autoantibody
- 16 of 28
Observational data: associations, not effects.
Further findings
Events
| Outcome | Prediabetes | T2D |
|---|---|---|
| Positive on 3Screen | 10 | 18 |
- Positive on 3Screen — Positive on 3Screen, all women
- 16%
Association of individual autoantibody positivity with clinical features
- Not associated with clinical and metabolic characteristics or markers of inflammation
Original publication
Islet autoimmunity in young First Nations women with prediabetes and type 2 diabetes. Diabetes Res Clin Pract. Published 30 October 2025. doi:10.
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