Intrinsic Capacity, Genetic Susceptibility and Incident Cardiovascular Disease Among Individuals With Diabetes: A Prospective Cohort Study
Main finding · PADResult — go to the resultHazard ratio 3.25 95% CI 2.44–4.33Authors' conclusion
In individuals with diabetes, a higher IC deficit score is associated with an increased risk of hypertension, ischemic heart disease, stroke, PAD, HF, and AF.
Study context
- Population
- Participants with DM (58.63 ± 7.54 years)
- Participants
- 18,333 participants
- Exposure
- Intrinsic capacity (IC) deficit score 4+ vs 0
- Outcome
- Incident hypertension, IHD, stroke, PAD, HF and AF
- Follow-up
- 9.91 to 13.43 years
Main finding
PAD
Hazard ratio
3.25
95% CI 2.44–4.33
IC deficit score 4+vs IC deficit score 0
HR 3.25 (95% CI 2.44–4.33)
As reported in the abstract
Observational data: associations, not effects.
Further findings
IHD by genetic risk
- Association between IC deficit score and IHD risk stronger in individuals with low genetic risk
CVD outcomes in high genetic risk
- Even with high genetic risk, IC deficit score 0 linked to lower risk of CVD outcomes
Original publication
Intrinsic Capacity, Genetic Susceptibility and Incident Cardiovascular Disease Among Individuals With Diabetes: A Prospective Cohort Study. Diabetes Obes Metab. Published 10 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →