Integrated multicompartment urinary long non-coding RNAs profiling (cellular, cell-free, and extracellular vesicle) for better differential diagnosis of biopsy-proven diabetic and non-diabetic kidney disease beyond conventional markers
Performance · Urinary cell-derived MALAT1 to differentiate DKD from NDKD (discovery cohort)Result — go to the resultOdds ratio 53.9Authors' conclusion
Urinary cell-derived MALAT1 improves the ability to differentiate DKD from NDKD over and above currently used clinical and biochemical parameters.
Study context
- Population
- Patients with T2D and biopsy-proven DKD or NDKD, T2D without kidney disease, and healthy subjectsn=40/group (discovery)
- Comparison
- Urinary Long non-coding RNAs (lncRNAs) for differentiating DKD from NDKD
- Outcome
- Differential expression of lncRNAs in DKD vs NDKD; diagnostic performance (ROC)
Methodological detailsdiscovery and independent validation cohorts, biopsy-proven
- Discovery and independent validation cohorts
- Biopsy-proven
Performance
As reported in the abstract
Urinary cell-derived MALAT1 to differentiate DKD from NDKD (discovery cohort)
Odds ratio
53.9
P < 0.0001
By group
Urinary cell-derived MALAT1
- Threshold
- ΔCt <8.3
- Sensitivity
- 90%
- Specificity
- 89.6%
- OR
- 53.9
Urinary cell-derived MALAT1
ThresholdΔCt <8.3
Sensitivity90%
Specificity89.6%
OR53.9
Further findings
| Outcome | Values |
|---|---|
| Urinary cell-derived MALAT1, validation cohort | Urinary cell-derived MALAT1 sensitivity 90% · specificity 88.5% |
Clinical utility: addition of MALAT1 to clinical/biochemical discriminators
- Net reclassification improvement (NRI)
- 0.53
- DKD cases correctly reclassified to higher probability (NRI+ = 0.280)
- 64%
- NDKD controls correctly reclassified to lower probability (NRI- = 0.250)
- 62.5%
Original publication
Integrated multicompartment urinary long non-coding RNAs profiling (cellular, cell-free, and extracellular vesicle) for better differential diagnosis of biopsy-proven diabetic and non-diabetic kidney disease beyond conventional markers. BMJ Open Diabetes Res Care. Published 25 May 2026. doi:10.
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