Insulin Use in Type 2 Diabetes and the Risk of Dementia: A Comparative Population-Based Cohort Study
Authors' conclusion
Among individuals with type 2 diabetes previously exposed to two noninsulin antihyperglycemic medications, no significant association was observed between insulin use and all-cause dementia.
Study context
- Population
- Patients with T2D diagnosed 1998–2016, British Columbia, Canada, previously receiving two noninsulin antihyperglycemic classes
- Participants
- 7,863 vs 25,230
- Exposure
- New insulin users vs new users of a noninsulin class
- Insulinn = 7,863
- Noninsulinn = 25,230reference
- Outcome
- All-cause dementia
Methodological detailscomparative new-user design, restricted cohort previously receiving two noninsulin antihyperglycemic classes, inverse probability of treatment weighting (IPTW) based on high-dimensional propensity score, competing risk (death)
- Comparative new-user design
- Restricted cohort previously receiving two noninsulin antihyperglycemic classes
- IPTW based on high-dimensional propensity score
- Competing risk (death)
Main finding
As reported in the abstract
Dementia · median follow-up 3.9 (IQR 5.9) years insulin; 4.6 (4.4) years noninsulin
Insulin
78
events
Noninsulin
179
events
Insulin vs NoninsulinHazard ratio (95% CI)
After IPTW
1.14(0.81–1.60)
After multivariable adjustment
1.39(1.05–1.86)
Before adjustment
1.68(1.29–2.20)
Observational data: associations, not effects.
Original publication
Insulin Use in Type 2 Diabetes and the Risk of Dementia: A Comparative Population-Based Cohort Study. Diabetes Care. Published 14 June 2023. doi:10.
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