Insulin Resistance Is Associated With Reduced Capillary Permeability of Thigh Muscles in Patients With Type 2 Diabetes
Authors' conclusion
The results signify that skeletal muscle DCE-MRI can be employed as a noninvasive technique for the assessment of muscle microcirculation in T2D. Our findings suggest that microvascular permeability of skeletal muscle is lowered in patients with T2D and that a decrease in microvascular permeability is associated with insulin resistance. These results are of interest with regard to the impact of muscle perfusion on diabetic complications such as diabetic sarcopenia.
Study context
- Population
- Patients with T2D and healthy controls undergoing DCE-MRI of the right thigh
- Participants
- 56 patients
- Exposure
- T2D vs healthy controls
- T2Dn = 46
- HCn = 10reference
- Outcome
- Feasibility of noninvasive assessment of skeletal muscle microcirculation via DCE-MRI (Ktrans, ve, vp)
Methodological detailsDCE-MRI at 3 Tesla
- DCE-MRI at 3 Tesla
Main finding
As reported in the abstract
Skeletal muscle Ktrans
P = 0.042
Observational data: associations, not effects.
Further findings
| Outcome | T2D | HC | P value |
|---|---|---|---|
| HOMA indexHigher with T2D | 6.11 ± 6.2 | 2.72 ± 2.2 | P = 0.011 |
Correlation of Ktrans with insulin and homeostasis model assessment (HOMA) index in T2D
- Ktrans vs insulin, r (P = .018)
- −0.39
- Ktrans vs HOMA index, r (P = .020)
- −0.38
Original publication
Insulin Resistance Is Associated With Reduced Capillary Permeability of Thigh Muscles in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. Published 15 August 2023. doi:10.
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