Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients
Main finding · Excellent functional outcome (mRS 0-1)Result — go to the resultAdjusted odds ratio 1.24 95% CI 1.06–1.45Authors' conclusion
eGDR is a predictor of functional outcome in patients with AIS, independent of traditional cardiovascular predictors.
Study context
- Population
- First-time acute ischemic stroke patients with available estimated glucose disposal rate (eGDR) data in CNSR-III
- Participants
- 6,271 patients
- Exposure
- Higher eGDR vs lower eGDR
- Outcome
- Excellent functional outcome (modified Rankin Scale score 0-1)
- Follow-up
- 3 months
Methodological detailsChina National Stroke Registry III (CNSR-III), univariate and multivariate analyses
- China National Stroke Registry III (CNSR-III)
- Univariate and multivariate analyses
Main finding
Excellent functional outcome (mRS 0-1)
Adjusted odds ratio
1.24
95% CI 1.06–1.45
P < 0.01
Higher eGDRvs Lower eGDR
aOR 1.24 (95% CI 1.06–1.45); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
eGDR value
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Favorable functional outcome (mRS 0-2) · one year | 1.55 (1.24–1.93) | P < 0.01 | |
| Excellent functional outcome (mRS 0-1) · one year | 1.28 (1.08–1.51) | P < 0.01 | |
| Stroke recurrence · 3 months | 0.81 (0.61–1.06) | P = 0.12 | |
| Stroke recurrence · one year | 0.91 (0.73–1.14) | P = 0.41 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients. Cardiovasc Diabetol. Published 26 August 2023. doi:10.
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