Insulin Requirements According to Sex and Weight in a Population of 9036 Adult Persons With Type 1 Diabetes Using Closed-Loop Insulin Delivery
Authors' conclusion
This large real-world analysis provides a quantitative estimation of the daily insulin requirements in adult patients with type 1 diabetes and shows significant differences between sex. These findings have relevant implications in the practical management of insulin therapy.
Study context
- Population
- Adults with T1D equipped in Europe with the Diabeloop Generation 1 (DBLG1) hybrid closed-loop insulin delivery device, March 2021–February 2023; 59% females, age 45.6 ± 14.3 years2,887,188 days of data
- Participants
- 9,036 adults
- Exposure
- Males vs females
- Outcome
- Daily insulin delivered per body weight (insulin-weight ratio) by sex
- Follow-up
- Mean 320 ± 143 days
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
Insulin-weight ratio
P < 0.001
- Overall mean insulin-weight ratio
- 0.617 ± 0.207 U/kg
Observational data: associations, not effects.
Further findings
| Outcome | Males | Females |
|---|---|---|
| Insulin-weight ratio in subset reaching >70% TIR (70-180 mg/dL)Exploratory analysis | 0.59 ± 0.18 | 0.53 ± 0.16 |
- Insulin-weight ratio in subset reaching >70% TIR (70-180 mg/dL) — Overall mean insulin-weight ratio, subset of 4066 (1438 males, 2628 females)
- 0.55 ± 0.17 U/kg (P < .001)
Original publication
Insulin Requirements According to Sex and Weight in a Population of 9036 Adult Persons With Type 1 Diabetes Using Closed-Loop Insulin Delivery. J Diabetes Sci Technol. Published 28 May 2024. doi:10.
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