Insulin-Like Growth Factor 1 and Risk of Cardiovascular Disease: Results From the UK Biobank Cohort Study
Authors' conclusion
This study indicates that both low and high levels of circulating IGF-1 are associated with increased risk of CVD in general population. These results highlight the importance of monitoring IGF-1 status on cardiovascular health.
Study context
- Population
- Participants without cardiovascular disease (CVD) and cancer at baseline, UK Biobank, with serum IGF-1 measured at baseline
- Participants
- 394,082 participants
- Exposure
- Lowest and highest IGF-1 quintiles vs third quintile
- Outcome
- Incident CVD, incl. CVD mortality, CHD, MI, HF and stroke
- Follow-up
- Median 11.6 years
Main finding
As reported in the abstract
Incident CVD · median 11.6 years
Each group vs third quintileHazard ratio (95% CI)
Lowest quintile
1.128(1.093–1.164)
Highest quintile
1.056(1.020–1.094)
- Incident CVD cases
- 35 803
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| CVD mortalityLowest quintilevs Third quintileMultivariable adjustment | 1.294 (1.181–1.418) | |
| CVD mortalityHighest quintilevs Third quintileMultivariable adjustment | 1.111 (1.000–1.236) | |
| CHDLowest quintilevs Third quintileMultivariable adjustment | 1.118 (1.078–1.159) | |
| CHDHighest quintilevs Third quintileMultivariable adjustment | 1.070 (1.028–1.114) | |
| MILowest quintilevs Third quintileMultivariable adjustment | 1.071 (1.008–1.139) | |
| MIHighest quintilevs Third quintileMultivariable adjustment | 1.111 (1.041–1.187) | |
| HFLowest quintilevs Third quintileMultivariable adjustment | 1.185 (1.107–1.268) | |
| HFHighest quintilevs Third quintileMultivariable adjustment | 1.098 (1.015–1.188) | |
| StrokeLowest quintilevs Third quintileMultivariable adjustment | 1.149 (1.070–1.235) | |
| 0.512Hazard ratio (log scale) |
- CVD mortality — CVD-related deaths
- 4231
- Coronary heart disease (CHD) — CHD cases
- 27 051
- Myocardial infarction (MI) — MI cases
- 10 014
- Heart failure (HF) — HF cases
- 7661
- Stroke — Stroke cases
- 6802
Original publication
Insulin-Like Growth Factor 1 and Risk of Cardiovascular Disease: Results From the UK Biobank Cohort Study. J Clin Endocrinol Metab. Published 22 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →