Insulin Discontinuation in Youth With New-Onset Type 2 Diabetes Presenting With and Without Diabetic Ketoacidosis
Authors' conclusion
Despite not showing differences in insulin discontinuation in youth with new-onset type 2 diabetes with and without DKA at presentation, we identified heterogeneity in duration of insulin treatment in the combined group.
Study context
- Population
- Youth hospitalized for new-onset T2D at an academic pediatric institution, January 2019 to December 2021, follow-up until May 2023; mean age 15 years (IQR 13, 16), BMI z-score 2.4 (IQR 2.07, 2.65); all initiated on insulin; T1D excluded by autoimmune antibodies
- Participants
- 79 vs 356
- Exposure
- T2D presenting with diabetic ketoacidosis (DKA) vs without DKA
- DKAn = 79
- non-DKAn = 356reference
- Outcome
- Time to insulin discontinuation and maintenance of discontinuation
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Insulin discontinuation (time to and proportion who discontinued)
P = 0.58
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| DKA at presentation and trajectory group (multinomial regression vs never discontinuation)DKA vs non-DKA · early discontinuation; not associated | P = 0.48 |
| DKA at presentation and trajectory group (multinomial regression vs never discontinuation)DKA vs non-DKA · late discontinuation; not associated | P = 0.70 |
Insulin discontinuation trajectory groups (DKA and non-DKA combined)
- Early discontinuation (within 2 months)
- 20.1%
- Late discontinuation (within 6 months)
- 12.5%
- Never discontinued
- 67.4%
Insulin restarted after discontinuation
- Participants with insulin restarted
- 37
- Time to restart after discontinuation, median (IQR)
- 20 months (16, 24)
Original publication
Insulin Discontinuation in Youth With New-Onset Type 2 Diabetes Presenting With and Without Diabetic Ketoacidosis. Endocr Pract. Published 15 October 2025. doi:10.
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