Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 (OLL2712) improves glycaemic control in adults with prediabetes in a randomized, double‐blind, placebo‐controlled trial
Authors' conclusion
The ingestion of OLL2712 prevents the deterioration of glycaemic control and maintains the HbA1c levels within the normal range in adults with prediabetes; yogurt probably exhibits similar effects, which may contribute to reducing the risk of developing type 2 diabetes.
Study context
- Population
- Healthy adults with prediabetes (HbA1c 5.6%-6.4%, age 20–64 years); followed 8 weeks after discontinuation
- Participants
- 148 adults
- Comparison
- Yogurt containing heat-treated OLL2712 cells vs conventional yogurt (placebo), daily for 12 weeks
- OLL2712n = 74
- Placebon = 74reference
- Primary endpoint
- Changes in HbA1c levels by analysis of covariance
- Follow-up
- Weeks 12 and 16
Methodological detailsdouble-blind, placebo-controlled, parallel-group
- Double-blind
- Placebo-controlled
- Parallel-group
Primary result
As reported in the abstract
Change in HbA1c
- OLL2712 vs Placebo: P = 0.014
- OLL2712 vs Placebo: P = 0.006
- Analysis of covariance
Further findings
HbA1c and glycoalbumin vs week 0 · weeks 12 and 16
- HbA1c and glycoalbumin decreased significantly in both groups at week 12 vs week 0, but only in the OLL2712 group at week 16
HbA1c · week 20
- No significant inter- and intragroup differences in HbA1c
Original publication
Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 improves glycaemic control in adults with prediabetes in a randomized, double‐blind, placebo‐controlled trial. Diabetes Obes Metab. Published 7 March 2024. doi:10.
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