Influence of Thyroglobulin Autoantibodies on Thyroglobulin Levels Measured by Different Methodologies: Immunometric Assay (IMA), LC-MS/Mass Spectrometry (MS), and Radioimmunoassay (RIA)
Authors' conclusion
(i) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. (ii) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS, and RIA). (iii) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.
Study context
- Population
- Tg autoantibody (TgAb)- and TgAb+ patients with distant metastatic differentiated thyroid cancer (DTC) or hyperthyroidism (HY), in whom detectable serum thyroglobulin (Tg) would be expected
- Comparison
- Tg measured by IMA vs LC-MS/MS vs RIA in TgAb- and TgAb+ patients
- Outcome
- Serum Tg detection and levels by TgAb status
Main finding
As reported in the abstract
TgAb-: all methods detected Tg in all DTC and HY patients and reported appropriate Tg trends and treatment responses in progressive distant metastatic DTC, with high between-method variability
> 30% coefficient of variability
TgAb+ DTC with no Tg detected by IMA or MS
∼50%
TgAb+ DTC with no Tg detected by RIA
6%
TgAb+ HY with no Tg detected by IMA or MS
5%
Original publication
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