Increased Levels of Urine Volatile Organic Compounds Are Associated With Diabetes Risk and Impaired Glucose Homeostasis
Authors' conclusion
Urinary metabolites of ambient VOCs are significantly associated with an increased diabetes risk and impaired glucose homeostasis. Thus, primary prevention policies aimed at reducing ambient VOCs could attenuate diabetes burden.
Study context
- Population
- General population, National Health and Nutrition Examination Survey1,504 with DM
- Participants
- 8,468 participants
- Exposure
- Urinary VOC metabolite exposure, single and mixed, vs diabetes and glucose homeostasis
- Outcome
- Diabetes mellitus and glucose homeostasis indicators
Methodological detailssurvey-weighted logistic and generalized linear regression, weighted quantile sum (WQS) regression for VOC mixtures
- Survey-weighted logistic and generalized linear regression
- Weighted quantile sum (WQS) regression for VOC mixtures
Main finding
As reported in the abstract
Individual VOC metabolites and DM, IR and glucose homeostasis
Eight VOC metabolites positively associated with DM (OR; all P < .05)
1.15-1.43
Positively associated with insulin resistance (IR) (OR; P < .05)
1.02-1.06
Positively associated with other glucose homeostasis indicators (β; all P < .05)
0.04-2.32
Observational data: associations, not effects.
Further findings
VOC mixture (WQS index) and DM, IR and glucose homeostasis
- WQS index and DM risk, OR
- 1.52 (95% CI 1.29-1.81)
- WQS index and IR, OR
- 1.36 (95% CI 1.14-1.62)
- WQS index and other glucose homeostasis indicators (β; all P < .05)
- 0.17-2.22
Original publication
Increased Levels of Urine Volatile Organic Compounds Are Associated With Diabetes Risk and Impaired Glucose Homeostasis. J Clin Endocrinol Metab. Published 4 October 2023. doi:10.
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