Association between estimated glomerular filtration rate slope and cardiovascular disease among individuals with and without diabetes: a prospective cohort study
Authors' conclusion
Monitoring the eGFR slope may serve as a potential predictor of CVD risk in individuals with diabetes.
Study context
- Population
- Adults aged 20–70 years, with DM (985) and without DM (5934), Tehran Lipid and Glucose Study (TLGS)
- Participants
- 6,919 adults
- Exposure
- Estimated glomerular filtration rate (eGFR) slope categories, in individuals with and without DM
- Outcome
- CVD events
- Follow-up
- Median 8.22 years after 9-year eGFR slope ascertainment period
Methodological detailsTehran Lipid and Glucose Study (TLGS), multivariable Cox proportional hazard model
- Tehran Lipid and Glucose Study (TLGS)
- Multivariable Cox proportional hazard model
Main finding
As reported in the abstract
CVD risk in individuals with DM, by eGFR slope
Slope −1.05 to −0.74 vs −0.51 to 0.16: higher cardiovascular disease (CVD) risk
2.12
Slope −0.60 to −0.52 vs −0.51 to 0.16: higher CVD risk
%64
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| eGFR slope · 9-year eGFR slope ascertainment periodBell-shaped distribution | With diabetes mean −0.63 (SD 0.13) ml/min per 1.73 m² per year · Without diabetes mean - 0.70 (SD 0.14) ml/min per 1.73 m² per year |
| CVD events · median follow-up 8.22 years | With diabetes 195 events |
- CVD events — Total CVD events
- 551
Original publication
Association between estimated glomerular filtration rate slope and cardiovascular disease among individuals with and without diabetes: a prospective cohort study. Cardiovasc Diabetol. Published 4 October 2023. doi:10.
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