Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry
Authors' conclusion
An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary.
Study context
- Population
- Children/adolescents aged 0.5-<18 years with new-onset T1D, German multicenter Diabetes Prospective Follow-up Registry (DPV)new-onset T1D
- Participants
- 30,840 participants
- Exposure
- Observed 2020 and 2021 pandemic rates vs rates predicted from pre-pandemic trends (2011 to 2019)
- Outcome
- Incidence of T1D
- Follow-up
- 2020 and 2021
Methodological detailsmulticenter, observed vs predicted from pre-pandemic trends 2011–2019, multivariable negative binomial or beta-binomial regression
- Multicenter
- Observed vs predicted from pre-pandemic trends 2011–2019
- Multivariable negative binomial or beta-binomial regression
Main finding
As reported in the abstract
Each group vs predictedEstimate (95% CI)
Observed
IRR 2020 1.13(1.08–1.19)
Observed
IRR 2021 1.20(1.15–1.26)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Incidence of DKA at diabetes onset · 2020 and 2021Observedvs PredictedAdjusted IRR | IRR 2020 1.34 (95% CI 1.23–1.46) | |
| Incidence of DKA at diabetes onset · 2020 and 2021Observedvs PredictedAdjusted IRR | IRR 2021 1.37 (95% CI 1.26–1.49) | |
| 0.512Ratio (log scale) |
| Outcome | Estimate |
|---|---|
| Prevalence of autoantibody-negative diabetes · 2020 and 2021Between Observed and Predicted | PRR 2020 0.91 (95% CI 0.75–1.10) |
| Prevalence of autoantibody-negative diabetes · 2020 and 2021Between Observed and Predicted | PRR 2021 1.03 (95% CI 0.86–1.24) |
Prevalence of autoantibody-negative diabetes · 2020 and 2021
- Prevalence did not change
Original publication
Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry. Diabetes Res Clin Pract. Published 8 February 2023. doi:10.
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