Improvement of Health‐Related Quality of Life and Mental Health After Unilateral Adrenalectomy for Primary Aldosteronism
Authors' conclusion
There was no difference in health-related QoL, anxiety and mental health in patients with hypertension with versus without PA. Unilateral adrenalectomy but not medical therapy improved health-related QoL and decreased anxiety in patients with PA.
Study context
- Population
- Patients with arterial hypertension tested for primary aldosteronism (PA)833 completed diagnostics
- Participants
- 925 patients
- Exposure
- Unilateral adrenalectomy vs MRA treatment in PA; PA vs hypertension without PA
- Unilateral PA after adrenalectomyn = 98
- Outcome
- Mental and physical health-related QoL (SF-12), anxiety (GAD-7) and depressive and panic symptoms (PHQ)
- Follow-up
- Baseline and 3-6 months after initiation of targeted therapy
Methodological detailsmulti-center, international
- Multi-center
- International
Main finding
As reported in the abstract
3-6 months after initiation of targeted therapy
SF-12 mental component summary improved after adrenalectomy (mean Δ)
4.2
p = 0.018
SF-12 physical component summary improved after adrenalectomy (Δ)
3.6
p = 0.038
GAD-7 improved after adrenalectomy (Δ)
−1.9
p = 0.006
Observational data: associations, not effects.
Further findings
Baseline quality of life (QoL), anxiety and mental health scores, PA vs hypertension without PA
- QoL, anxiety and mental health scores did not differ in PA vs hypertension without PA
PA diagnosis
- Diagnosed with PA among 833 who completed diagnostics
- 211
- Unilateral PA receiving unilateral adrenalectomy
- 98 of 116
Original publication
Improvement of Health‐Related Quality of Life and Mental Health After Unilateral Adrenalectomy for Primary Aldosteronism. Clin Endocrinol (Oxf). Published 8 March 2026. doi:10.
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