Improvement in Newly Defined Continuous Glucose Monitor Metrics, Extended Hypoglycemia, and Extended Hyperglycemia With Automated Insulin Delivery Initiation in Adults With Type 1 Diabetes
Authors' conclusion
Automated insulin delivery initiation significantly improved Ehypo and Ehyper metrics. Ehypo and Ehyper had a strong positive correlation with TBR and TAR, respectively. Ehypo and Ehyper events can be used in addition to TBR and TAR metrics in clinical studies as secondary outcomes.
Study context
- Population
- Adults with T1D who initiated an automated insulin delivery (AID) system
- Participants
- 154 adults
- Exposure
- After vs before AID initiation
- Outcome
- Changes in extended hypoglycaemia (Ehypo) and extended hyperglycaemia (Ehyper) CGM metrics
Methodological detailssingle-centre, before–after comparison
- Single-centre
- Before–after comparison
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Ehyper (>250 mg/dL) events/week · Wilcoxon signed-rank test; decreased after AID · co-primary metric with Ehypo
P < 0.001
Other continuous glucose monitoring (CGM) metrics
- All other CGM metrics improved after AID initiation
Correlation of extended hyperglycemia (Ehyper) (>250 mg/dL) with mean glucose, GMI and time above range (TAR) (>180 mg/dL)
- Ehyper vs mean glucose, before AID
- r = 0.947
- Ehyper vs mean glucose, after AID
- r = 0.894
- Ehyper vs GMI, before AID
- r = 0.947
- Ehyper vs GMI, after AID
- r = 0.887
- Ehyper vs TAR, before AID
- r = 0.957
- Ehyper vs TAR, after AID
- r = 0.917
Correlation of extended hypoglycemia (Ehypo) (<70 mg/dL) with time below range (TBR) (<70 mg/dL)
- Ehypo vs TBR, before AID
- r = 0.823
- Ehypo vs TBR, after AID
- r = 0.608
Original publication
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