The Importance of Instigating Automated Insulin Delivery Systems at Onset of Type 1 Diabetes: 1-Year Follow-Up of Children and Adolescents from Two Tertiary Pediatric Diabetes Centers
Study context
- Population
- Children and adolescents aged 0–18 years with T1D onset between January 1, 2020, and June 30, 2023; mean age 7.9 ± 3.9 years (range 1–18), 58 male
- Participants
- 84 children
- Exposure
- Automated insulin delivery (AID) vs predictive low-glucose suspend (PLGS) vs multiple daily injections (MDI) started in the first month of diabetes management
- AIDn = 32
- PLGSn = 28
- MDIn = 24reference
- Outcome
- HbA1c
- Follow-up
- 12 months
Methodological detailsreal-world, two tertiary pediatric diabetes centers, switching allowed after first 3 months
- Real-world
- Two tertiary pediatric diabetes centers
- Switching allowed after first 3 months
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CGM metrics: TIR, TBR, TAR, CV, GMI · 12 monthsAID vs PLGS or MDI · better with AID | P = 0.001 |
| CGM metrics: TIR, TBR, TAR, CV, GMI · 12 monthsAID vs PLGS or MDI · better with AID | P = 0.01 |
| CGM metrics: TIR, TBR, TAR, CV, GMI · 12 monthsAID vs PLGS or MDI · better with AID | P = 0.001 |
| CGM metrics: TIR, TBR, TAR, CV, GMI · 12 monthsAID vs PLGS or MDI · better with AID | P = 0.01 |
| CGM metrics: TIR, TBR, TAR, CV, GMI · 12 monthsAID vs PLGS or MDI · better with AID | P = 0.001 |
Original publication
The Importance of Instigating Automated Insulin Delivery Systems at Onset of Type 1 Diabetes: 1-Year Follow-Up of Children and Adolescents from Two Tertiary Pediatric Diabetes Centers. Diabetes Technol Ther. Published 20 March 2025. doi:10.
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