Impaired Physical Performance in X-linked Hypophosphatemia Is not Caused by Depleted Muscular Phosphate Stores
Authors' conclusion
The content of phosphoric compounds within the musculature of patients with XLH was not observed to be different from controls. Volume-adjusted muscle strength and fatiguability were not different either. Reduced physical performance in patients with XLH may result from long-term adaptation to reduced physical activity due to skeletal impairment.
Study context
- Population
- Adults aged 18–65 years with X-linked hypophosphatemia (XLH) and matched controls; assessment at the German Aerospace Center (DLR), Cologne, May–December 2019matched case-control
- Participants
- 13 vs 13
- Comparison
- XLH vs matched controls
- XLHn = 13
- Controlsn = 13reference
- Outcome
- 31P-MRS-based assessment of phosphate metabolites in the soleus muscle at rest
Methodological detailsage/sex/body weight-matched controls, 1-time assessment
- Age/sex/body weight-matched controls
- 1-time assessment
Main finding
As reported in the abstract
Soleus muscle phosphate metabolites at rest (31P-MRS)
- No significant differences between XLH and controls in phosphate metabolites except a slightly increased PCr/Pi ratio
- XLH vs Controls: P = 0.023
Observational data: associations, not effects.
Further findings
| Outcome | XLH | Controls | P value |
|---|---|---|---|
| Quadriceps muscle volumeReduced in XLH | 812.1 ± 309.0 mL | 1391.1 ± 306.2 mv | P < 0.001 |
- Jumping peak power and jump height · significantly reduced in XLH
- both P < .001
Isokinetic maximum torque (maximum voluntary contraction (MVC)) adjusted to quadriceps muscle volume
- No significant differences between XLH and controls
Original publication
Impaired Physical Performance in X-linked Hypophosphatemia Is not Caused by Depleted Muscular Phosphate Stores. J Clin Endocrinol Metab. Published 12 April 2023. doi:10.
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