Impaired Dietary Decision-Making in Children and Adolescents with Congenital Adrenal Hyperplasia
Authors' conclusion
Children and adolescents with CAH exhibit more cognitive conflict when choosing between healthy and tasty foods. Two indicators of disease severity were associated with cognitive conflict during food choice in patients with CAH. Our findings suggest impaired dietary decision-making in CAH could contribute to obesity risk.
Study context
- Population
- Children and adolescents with congenital adrenal hyperplasia (CAH) and controls; rated 30 low- and 30 high-calorie foods for health, taste and liking, then chose between 100 food pairs (75 discordant for health and taste)
- Participants
- 37 vs 100
- Exposure
- Youth with CAH vs controls
- CAHn = 37
- Controlsn = 100reference
- Outcome
- AUC (real-time index of decision-making) in self-control trials
Methodological detailsmouse-tracking paradigm
- Mouse-tracking paradigm
Main finding
As reported in the abstract
CAH
9.48
± 8.08
Controls
6.40
± 7.33
P < 0.05
Observational data: associations, not effects.
Further findings
Self-control success (% trials healthier food chosen over tastier) · did not differ
P = 0.16
| Outcome | CAH | Controls | P value |
|---|---|---|---|
| Maximum deviation (MD) in self-control trialsHigher with CAH | 0.20 ± 0.13 | 0.15 ± 0.12 | P < 0.05 |
Testosterone correlation with AUC and MD during successful self-control trials (CAH)
- Testosterone vs AUC
- R = 0.46, p < 0.01
- Testosterone vs MD
- R = 0.38, p = 0.02
Original publication
Impaired Dietary Decision-Making in Children and Adolescents with Congenital Adrenal Hyperplasia. Horm Res Paediatr. Published 11 March 2025. doi:10.
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