Impact of Overnight Glucose on Next-Day Functioning in Adults With Type 1 Diabetes: An Exploratory Intensive Longitudinal Study
Authors' conclusion
Overnight glucose predicts problems with objective and self-reported next-day functioning and can adversely impact global patient-reported outcomes. These findings across diverse outcomes highlight the wide-ranging effects of glucose fluctuations on functioning in adults with type 1 diabetes.
Study context
- Population
- Adults with T1D
- Outcome
- Seven next-day functioning outcomes (mobile cognitive tasks, accelerometry-derived physical activity, self-reported activity participation) predicted from overnight glucose (CV, % time <70 mg/dL, % time >250 mg/dL)
- Follow-up
- Next day
Methodological detailsexploratory, dynamic structural equation modeling
- Exploratory
- Dynamic structural equation modeling
Main finding
As reported in the abstract
Overall next-day functioning
- Predicted from overnight CV
- P = 0.017
- Predicted from overnight % time >250 mg/dL
- P = 0.037
- Higher CV associated with poorer sustained attention
- P = 0.028
- Higher CV associated with lower engagement in demanding activities
- P = 0.028
- Time <70 mg/dL associated with poorer sustained attention
- P = 0.007
- Time >250 mg/dL associated with more sedentary time
- P = 0.024
Observational data: associations, not effects.
Further findings
Mediation of CV effect on sustained attention
- Impact of CV on sustained attention partially mediated by sleep fragmentation
Individual differences in effect of overnight time <70 mg/dL on sustained attention predicting global patient-reported outcomes
- Predict global illness intrusiveness
- P = 0.016
- Predict diabetes-related quality of life
- P = 0.036
Original publication
Impact of Overnight Glucose on Next-Day Functioning in Adults With Type 1 Diabetes: An Exploratory Intensive Longitudinal Study. Diabetes Care. Published 2 March 2023. doi:10.
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