Impact of gestational diabetes mellitus treatment on medium/long‐term outcomes after pregnancy: A systematic review and meta‐analysis
Authors' conclusion
With current evidence is uncertain if specific treatment of women with GDM has an impact on medium/long-term metabolic outcomes either in the mother or in the offspring. These results add evidence to the recommendation of systematically reevaluating mother and offspring after delivery.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) and their offspring; RCTs with follow-up 4–16 years after delivery
- Participants
- 1,140 women5 studies
- Comparison
- Specific GDM treatment vs usual care
- Outcome
- Maternal diabetes and metabolic syndrome; offspring diabetes, impaired fasting glucose, impaired glucose tolerance, high BMI
- Follow-up
- Medium/long-term (4-16 years after delivery)
Methodological detailsRisk of bias assessed with Cochrane tool; aggregation with Revman 5.4, MEDLINE, EMBASE and CENTRAL searched from inception to 8 October 2021
- Risk of bias assessed with Cochrane tool; aggregation with Revman 5.4
- MEDLINE, EMBASE and CENTRAL searched from inception to 8 October 2021
Pooled result
As reported in the abstract
4-16 years after delivery
GDM treatment vs Usual careRelative risk (95% CI)
Maternal diabetes
1.00(0.82–1.23)
Maternal metabolic syndrome
0.93(0.71–1.22)
Offspring impaired fasting glucose
0.79(0.39–1.69)
Offspring BMI >85th centile
0.91(0.74–1.12)
Offspring BMI >95th centile
0.89(0.65–1.22)
Further pooled results
- Very uncertain evidence that treatment may increase maternal HDL-C
Original publication
Impact of gestational diabetes mellitus treatment on medium/long‐term outcomes after pregnancy: A systematic review and meta‐analysis. Diabet Med. Published 17 November 2022. doi:10.
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