Impact of Early Life Factors on Metabolic Phenotypes of Obesity in Preschool Children
Authors' conclusion
Early life factors, such as maternal obesity and accelerated BMI growth rate between 6 and 24 months, were related not only to MHO but also to MUO. Children with these early life factors should be given interventions for weight control to prevent metabolic abnormalities.
Study context
- Population
- 3-year-old preschool children3,015 analyzed
- Participants
- 3,822 children
- Exposure
- Early life factors and metabolic phenotypes of obesity
- Outcome
- Metabolic phenotypes of obesity (MHNW, MUNW, MHO, MUO) by BMI and metabolic status
Main finding
As reported in the abstract
Each group vs MHNWEstimate (95% CI)
MHO
OR (maternal overweight before pregnancy) 3.16(1.55–6.42)
MHO
OR (maternal obesity before pregnancy) 8.14(3.73–17.76)
MHO
OR (macrosomia) 2.47(1.32–4.59)
MUO
OR (maternal obesity before pregnancy) 6.35(2.17–18.52)
- MHO
- β (accelerated BMI z score growth rate 6–24 months) 0.022 (95% CI 0.009–0.036)
- MUO
- β (accelerated BMI z score growth rate 6–24 months) 0.037 (95% CI 0.018–0.056)
Observational data: associations, not effects.
Original publication
Impact of Early Life Factors on Metabolic Phenotypes of Obesity in Preschool Children. Diabetes Care. Published 16 March 2023. doi:10.
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