Impact of diabetes on long-term mortality following major lower limb amputation: A population-based cohort study in Wales
Main finding · 5-year mortalityResult — go to the resultHazard ratio 1.62Authors' conclusion
Time-stratified analysis demonstrates lower short-term but higher long-term mortality risk for persons with diabetes following major amputation. Further research is required to explore interventions aimed at improving survival.
Study context
- Population
- Persons ≥ 18 years with incident major lower limb amputation, 2006 to 2013, Wales (SAIL Databank)48.4 % had diabetes
- Participants
- 2,542 persons
- Exposure
- Diabetes vs no diabetes
- Outcome
- Long-term (5-year) mortality
- Follow-up
- 5-year follow-up
Methodological detailsCox regression stratified by amputation level, time-stratified analysis
- Cox regression stratified by amputation level
- Time-stratified analysis
Main finding
5-year mortality · 5 years
Hazard ratio
1.62
P < 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
30-day mortality
- Overall mortality at 30 days
- 9.2 %
- Diabetes associated with a reduced risk of death in the first 30 days post-amputation
Overall 5-year mortality
- Mortality within 5 years, all patients
- 61.9 %
Predictors of mortality
- History of peripheral vascular disease and above-knee amputation were strong predictors of mortality
Original publication
Impact of diabetes on long-term mortality following major lower limb amputation: A population-based cohort study in Wales. Diabetes Res Clin Pract. Published 9 April 2025. doi:10.
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