Impact of diabetes mellitus on myocardial function and clinical outcomes in patients with significant aortic regurgitation
Authors' conclusion
In patients with AR, T2DM exerts an additive deleterious effect on both LA and LV function and is an independent predictor of MACEs. These findings underscore the need for earlier evaluation and intervention targeting cardiac function in the context of AR complicated by T2DM.
Study context
- Population
- Patients with aortic regurgitation (AR), with or without T2DM, and age-matched healthy individuals
- Participants
- 255 AR patients
- Exposure
- AR with T2DM vs AR without T2DM
- Controlsn = 65
- Outcome
- MACE
- Follow-up
- Median 29 months
Methodological detailsechocardiographic, age-matched healthy controls
- Echocardiographic
- Age-matched healthy controls
Main finding
As reported in the abstract
AR(T2DM+) vs AR(T2DM-)Hazard ratio (95% CI)P value
Multivariable, aortic valve surgery as time-dependent covariate
2.22(1.12–4.38)
P = 0.022- MACE
- χ2 20.10; P < 0.001
- Total major adverse cardiac events (MACEs) recorded
- 42
Observational data: associations, not effects.
Further findings
Left ventricular (LV) and left atrial (LA) volumes and ejection fractions
- Both AR groups had increased LV and LA volumes and reduced LV and LA ejection fractions vs controls
- all P < 0.05
LV global longitudinal strain (LVGLS) and left atrial reservoir strain (LARS)
- Progressive decline from controls to AR(T2DM-) to AR(T2DM+)
- all P < 0.05
- T2DM independently associated with impaired LVGLS and LARS in AR
- both P < 0.05
Original publication
Impact of diabetes mellitus on myocardial function and clinical outcomes in patients with significant aortic regurgitation. Cardiovasc Diabetol. Published 15 July 2025. doi:10.
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