Impact of Metformin Plus Lifestyle Intervention Compared With Lifestyle Intervention Alone on Prediabetes Remission in Participants With Impaired Glucose Regulation: The China DPP Study
Primary result · Prediabetes remissionResult — go to the resultHR for remission 1.39 95% CI 1.16–1.67Authors' conclusion
Adding metformin to a lifestyle intervention significantly improved prediabetes remission rates over lifestyle intervention alone in Chinese adults with impaired glucose regulation.
Study context
- Population
- Adults aged 18–70 years with impaired glucose regulation, 43 hospitals across China
- Participants
- 1,678 adults
- Comparison
- Metformin plus lifestyle intervention vs lifestyle intervention alone
- Metformin plus lifestylen = 831
- Lifestyle alonen = 847reference
- Primary endpoint
- Prediabetes remission rate
Methodological detailsmulticentre, unblinded, block randomisation, 1:1
- Multicentre
- Unblinded
- Block randomisation
- 1:1
Primary result
Prediabetes remission · median follow-up 2.03 years
HR for remission
1.39
95% CI 1.16–1.67
P < 0.001
Events by treatment group
Metformin + lifestylevs Lifestyle alone
HR for remission 1.39 (95% CI 1.16–1.67); P < 0.001
As reported in the abstract
Further findings
| Outcome | Metformin plus lifestyle | Lifestyle alone |
|---|---|---|
| Remission in men | ||
| Denominator | 396 | 397 |
| Remission in women | ||
| Denominator | 435 | 450 |
Subgroups
- Similar effects across subgroups
Higher baseline HbA1c and remission
- Higher baseline HbA1c associated with lower remission rates
- HR 0.23 (95% CI 0.18-0.29, p < 0.001)
Original publication
Impact of Metformin Plus Lifestyle Intervention Compared With Lifestyle Intervention Alone on Prediabetes Remission in Participants With Impaired Glucose Regulation: The China DPP Study. Diabetes Obes Metab. Published 26 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →