Impact in real-world of intermittent-scanned continuous glucose monitoring with alarms on hypoglycemia and its recognition in type 1 diabetes
Authors' conclusion
In the real-world, long-term use of isCGM could reduce both hypoglycemic episodes and IAH in people with T1D.
Study context
- Population
- Subjects with T1D who experienced frequent hypoglycemic events
- Participants
- 60 subjects
- Exposure
- Intermittently scanned continuous glucose monitoring (isCGM) with alarms at 2 years vs initial 2 weeks
- Outcome
- Glucometric parameters, IAH and hypoglycemia fear
- Follow-up
- 2 years
Methodological detailsreal-world, observational, 2 years of follow-up
- Real-world
- Observational
- 2 years of follow-up
Main finding
As reported in the abstract
- Glucose variability (%), mean ± SD
- 40.3 ± 0.8 % vs. 37.1 ± 0.9 %, p = 0.003
- Time in low glucose range (54-69 mg/dL)
- 5.2 ± 0.4 % vs. 3.6 ± 0.3 %, p = 0.001
- Time in very low glucose range (<54 mg/dL)
- 3.2 ± 0.5 % vs. 0.8 ± 0.2 %, p < 0.001
- Events related to low glucose levels
- 10.6 ± 1.1 vs 8.0 ± 1.0, p = 0.042
- Duration of hypoglycemia episodes
- 106.1 ± 5.9 min vs. 85.7 ± 5.7 min, p = 0.008
- Impaired awareness of hypoglycemia (IAH) frequency (Clarke questionnaire), reduction of 47 %
- 24.6 % vs. 11.6 %, p = 0.034
- Hypoglycemia fear (Hypoglycemia Fear Survey (HFS))
- 77.8 ± 2.4 vs 68.2 ± 2.1, p < 0.001
Observational data: associations, not effects.
Further findings
Total insulin dose · 2 years
- Reduction in total insulin dose
- 0.64 ± 0.30 UI/Kg/day vs 0.56 ± 0.11 UI/Kg/day, p = 0.018
Original publication
Impact in real-world of intermittent-scanned continuous glucose monitoring with alarms on hypoglycemia and its recognition in type 1 diabetes. Diabetes Res Clin Pract. Published 17 July 2024. doi:10.
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