IFN-α Neutralizing Antibodies Distinguish Latent Autoimmune Diabetes in Adults (LADA) From Early-onset Type 1 Diabetes
Authors' conclusion
Autoimmunity against IFN-α is peculiar to autoimmune diabetes and appears to be distinctive to its slowly progressive forms. Understanding the underlying molecular mechanisms and clinical significance of this novel autoimmunity could lead to the development of new therapeutic strategies in autoimmune diseases, advancing personalized medicine.
Study context
- Population
- People with LADA or early-onset T1D; serum AAb-IFN-α isoforms measured
- Participants
- 41 vs 90
- Exposure
- LADA vs early-onset T1D
- LADAn = 41
- T1Dn = 90reference
- Outcome
- Difference between LADA and T1D in proportion positive for AAb against ≥2 IFN-α isoforms
Methodological detailscell-based assay
- Cell-based assay
Main finding
As reported in the abstract
Positivity for AAb against ≥2 IFN-α isoforms
P = 0.011
Observational data: associations, not effects.
Secondary outcomes
| Outcome | LADA | T1D | P value |
|---|---|---|---|
| Positivity for AAb against 3 IFN-α isoforms | 12.2% | 0 events | P = 0.0025 |
FPG and HbA1c in LADA by AAb-IFN-α status
- FPG and HbA1c numerically lower in LADA positive for AAb against ≥2 IFN-α isoforms than in those negative or positive for 1 isoform
Correlation of AAb-IFN-α2 with GADA levels in AAb-positive LADA
- Inverse correlation, rho
- −0.513; P = .025
Original publication
IFN-α Neutralizing Antibodies Distinguish LADA From Early-onset Type 1 Diabetes. J Clin Endocrinol Metab. Published 6 January 2025. doi:10.
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