Identifying metabotypes of insulin resistance severity in children with metabolic syndrome
Authors' conclusion
Altogether, these findings suggest that insulin resistance could encompass several phenotypic subtypes characterized by graded disturbances in distinctive metabolic derangements occurring in childhood obesity, which serve as severity predictive markers.
Study context
- Population
- Children with obesity and insulin resistance; fasting and postprandial plasma and erythrocytes collected for metabolomics
- Comparison
- Late vs middle vs early post-OGTT insulin peak
- Outcome
- Cardiometabolic health and metabolomic profile by insulin peak timing
Main finding
As reported in the abstract
- Late insulin peak: worse cardiometabolic health (higher blood pressure, glycemia and HOMA-IR) than early responders
- Late peak: more pronounced changes in metabolites of energy homeostasis, oxidative stress, cholesterol and phospholipid metabolism, and unhealthy dietary habits
- Delayed insulin peak associated with impaired metabolic flexibility (mitochondrial energy pathways and antioxidant defense in response to glucose overload)
Original publication
Identifying metabotypes of insulin resistance severity in children with metabolic syndrome. Cardiovasc Diabetol. Published 27 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →