Identifying Children With Obesity at High Risk for Metabolic Syndrome: Sensitivity and Specificity of the Monocyte/HDL Index
Authors' conclusion
MHR is the best proxy of MetS and reveals the early elevation of proinflammatory factors in childhood, suggesting that it serves as a diagnostic tool in patients under 10 years of age, where the identification of MetS is controversial.
Study context
- Population
- Prepubertal children with obesity
- Participants
- 79 vs 75
- Exposure
- Children fulfilling Metabolic Syndrome (MetS) IDF criteria vs control children; diagnostic performance of MHR, NLR, PLR and LMR
- MetSn = 79
- Controln = 75reference
- Outcome
- Sensitivity and specificity of MHR, NLR, PLR and LMR to identify clinical characteristics of MetS (ROC curves)
Methodological detailsprospective, Blood glucose, lipid profile, ESR, usCRP and complete blood count determined; ratios calculated manually
- Prospective
- Blood glucose, lipid profile, ESR, usCRP and complete blood count determined; ratios calculated manually
Main finding
As reported in the abstract
Diagnostic performance of haematological indices for MetS
MHR was the most sensitive and specific haematological index to determine clinical characteristics of MetS; cut-off point
8.62
Observational data: associations, not effects.
Original publication
Identifying Children With Obesity at High Risk for Metabolic Syndrome: Sensitivity and Specificity of the Monocyte/HDL Index. Pediatr Obes. Published 8 July 2025. doi:10.
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