Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study
Authors' conclusion
HDAP can be common in individuals without diabetes and is associated with early-onset diabetes following AP. Individuals without HDAP have a low risk of diabetes short term, while those with HDAP200 are at high risk. Monitoring glycemia during AP can identify individuals best suited for early targeted postdischarge care.
Study context
- Population
- Participants without prior diabetes with an acute pancreatitis (AP) episode (DREAM study)
- Participants
- 395 participants
- Exposure
- Hyperglycemia during acute pancreatitis (HDAP) vs no HDAP
- Outcome
- Prevalence of HDAP and its prognostic significance for early-onset diabetes after AP (fasting glucose, OGTT, HbA1c)
- Follow-up
- Median: 111 days post-AP
Methodological detailsmulticenter, preliminary findings
- Multicenter
- Preliminary findings
Main finding
As reported in the abstract
Prevalence of HDAP; early-onset diabetes after AP recovery
HDAP140 prevalence
37.5%
HDAP200 prevalence
7.1%
Observational data: associations, not effects.
Further findings
Predictors of HDAP140
- Age, race, etiology and AP severity were significant predictors of HDAP140
NPV of absence of HDAP for diabetes
- NPV of absence of HDAP140 for diabetes
- 99%
- NPV of absence of HDAP200 for diabetes
- 97%
Original publication
Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study. Diabetes Care. Published 6 April 2026. doi:10.
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