Hospitalizations and outcomes in congenital adrenal hyperplasia across the lifespan: a population-based cohort study
Authors' conclusion
Across all age groups, CAH is associated with earlier and more complex hospitalizations and higher risk of severe in-hospital outcomes than in control groups, particularly in early life.
Study context
- Population
- Nationwide Swiss hospital data (2011–2022), stratified into neonates and infants, young children, children and adolescents, and adults
- Participants
- 12,569,835 hospitalizations
- Exposure
- Hospitalizations with congenital adrenal hyperplasia (CAH) vs all other hospitalizations without CAH
- CAHn = 2,020
- Outcome
- Hospitalization incidence and main reasons for admission, CAH vs non-CAH hospitalizations, by age group
Methodological detailsnationwide, age-stratified
- Nationwide
- Age-stratified
Main finding
As reported in the abstract
Endocrine and metabolic disorders as leading cause of admission, neonates and infants
OR 66.5
95% CI 8.88–498.07
Endocrine and metabolic disorders as leading cause of admission, young children
OR 21.42
95% CI 4.67–98.20
Endocrine and metabolic disorders as leading cause of admission, children and adolescents
OR 53.32
95% CI 7.08–401.72
Endocrine and metabolic disorders as leading cause of admission, adults
OR 2.61
95% CI 1.53–4.46
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| ICU admission | 1.55 (1.20–2.01) | |
| 0.512Odds ratio (log scale) |
| Outcome | CAH |
|---|---|
| Comorbidity burden (diagnoses per hospitalization)At birth | mean 5.5 diagnoses per hospitalization |
Hospitalization incidence
- Highest in neonates and infants and young children in CAH; increased with age in controls
Comorbidity burden (diagnoses per hospitalization)
- Substantially higher in CAH across the lifespan; mean 5.5 at birth vs similar burden only around age 60 in controls
ICU admission
- Increased risk of severe in-hospital outcomes, largest differences in neonates/infants
Original publication
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