Hospitalization of Patients With Diabetes Due to Ketoacidosis Before and After the Initiation of Sodium-Glucose Cotransporter-2 Inhibitors
Authors' conclusion
The rate of hospitalizations because of DKA remained stable before and 5 years after SGLT2I were implemented for the treatment of type 2 diabetes mellitus. Larger, multi-institutional studies with longer follow-ups are needed to study the effect of SGLT2I on the rate of hospitalizations because of DKA among people with diabetes. Although DKA events associated with SGLT2I are rare, they should be strongly considered in the differential diagnosis of people treated with these medications.
Study context
- Population
- Adults hospitalized with a diagnosis of diabetic ketoacidosis (DKA) in a tertiary referral center, 2011–2019
- Participants
- 186 hospitalizations
- Exposure
- Pre-SGLT2i era vs post-SGLT2i era
- Outcome
- Incidence of hospitalization because of DKA
Methodological detailssingle tertiary referral centre
- Single tertiary referral centre
Main finding
As reported in the abstract
Rate of hospitalization stable during 2011-2019
0.22% ± 0.04%
95% CI 0.18–0.25
Observational data: associations, not effects.
Further findings
Clinical characteristics of people hospitalized with DKA
- Clinical characteristics in 2011-2014 similar to 2015-2019
Safety
- SGLT2i-related DKA · 2015-2019 — 2015-2019
- 6.1%
SGLT2i-related DKA · 2015-2019
- Clinical characteristics of SGLT2i-related DKA similar to rest of cohort
Original publication
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