Higher risk of incident diabetes among patients with primary hyperparathyroidism
Main finding · Incident diabetesResult — go to the resultHazard ratio 1.15 95% CI 1.04–1.28Authors' conclusion
Patients with PHPT had a higher risk of incident diabetes compared to non-PHPT individuals. A positive linear association was found between serum calcium concentrations and the risk of incident diabetes in patients with PHPT.
Study context
- Population
- Patients with primary hyperparathyroidism (PHPT) and matched non-PHPT individuals, 2000–2019matched cohort
- Participants
- 2,749 vs 13,745
- Exposure
- PHPT vs non-PHPT
- PHPTn = 2,749
- non-PHPTn = 13,745reference
- Outcome
- Incident diabetes
- Follow-up
- Median 5.17 years (IQR 2.17, 9.58)
Methodological detailsmatched on age, sex and index year
- Matched on age, sex and index year
Main finding
As reported in the abstract
median follow-up 5.17 years
Hazard ratio
1.15
95% CI 1.04–1.28
Events by group
PHPTvs non-PHPT
HR 1.15 (95% CI 1.04–1.28)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident diabetes in PHPT by serum calcium abovevs below the median (2.63 mmol/L) | 1.44 (1.08–1.90) | |
| 0.512Hazard ratio (log scale) |
Serum calcium and incident diabetes risk in PHPT (restricted cubic spline)
- Positive linear association; p-value for nonlinear
- .751
Original publication
Higher risk of incident diabetes among patients with primary hyperparathyroidism. Clin Endocrinol (Oxf). Published 22 July 2024. doi:10.
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