Higher Parametric Thyroid Feedback Quantile-based Index Is a Predictor of Type 2 Diabetes in a German Population Sample
Authors' conclusion
An elevation of the pituitary TSH-inhibition threshold is associated with incident type 2 diabetes independently of BMI. The PTFQI might have clinical potential for prognosis and metabolic status monitoring.
Study context
- Population
- Adults aged 20 to 79 years without diabetes or thyroid medication at baseline, population-based Study of Health in Pomerania (SHIP), Germanyof 4308 sampled
- Participants
- 2,542 adults
- Exposure
- PTFQI quartiles 2–4 vs first quartile
- Outcome
- Incident T2D by baseline PTFQI (calculated from free thyroxine (fT4) and TSH)
- Follow-up
- 5 years
Methodological details5-year follow-up, Poisson regression adjusted for age, sex and body mass index (BMI)
- 5-year follow-up
- Poisson regression adjusted for age, sex and BMI
Main finding
As reported in the abstract
Incident T2D, adjusted for age and sex
Incidence rate ratio (95% CI)P value
Q2vs Q1
1.54(0.97–2.46)
Q3vs Q1
1.55(0.94–2.57)
Q4vs Q1
1.97(1.27–3.10)
P = 0.004for trendObservational data: associations, not effects.
Further findings
| Outcome | IRR (CI) | P value | |
|---|---|---|---|
| Incident T2D, additionally adjusted for BMI · 5 yearsQ4vs Q1 | 1.64 (1.05–2.59) | P for trend = 0.043 | |
| 0.20.5125Incidence rate ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Higher Parametric Thyroid Feedback Quantile-based Index Is a Predictor of Type 2 Diabetes in a German Population Sample. J Clin Endocrinol Metab. Published 29 February 2024. doi:10.
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